A great deal has been learned in the decade since the first results from the Women’s Health Initiative (WHI) were published on July 9, 2002. The WHI was the largest and longest trial of postmenopausal women using hormone therapy (HT). The 27,000 women were prescribed estrogen-alone therapy, estrogen-progestogen therapy, or a placebo for 5 to 7 years, respectively.
Researchers expected to find that hormones prevented chronic conditions of aging in women, including heart disease. Instead, they found that hormones produced a mix of risks and benefits. The subsequent data from the WHI suggest that the risks of HT vary with a woman’s age (safer if started soon after menopause). [Read more…]